Thrombolytic therapy in prosthetic valve thrombosis during early pregnancy.

Regardless of the improvements in the design of prosthetic heart valves and the use of anticoagulation, systemic embolism and valve thrombosis remains the most dreaded complications of mechanical heart valve replacement. A course of thrombolytic therapy may be considered as a first-line therapy for prosthetic heart valve thrombosis. The safety of thrombolysis in early pregnancy is not known. We describe a primigravida with mitral valve replacement status presenting with acute prosthetic valve thrombosis and treated successfully with intravenous streptokinase.
AuthorsB C Srinivas, Nagaraja Moorthy, Arora Kuldeep, Harsha Jeevan, Danalakshmi Chandrasekaran, C N Manjunath
JournalIndian heart journal (Indian Heart J) 2012 Jan-Feb Vol. 64 Issue 1 Pg. 74-6 ISSN: 0019-4832 [Print] India
PMID22572429 (Publication Type: Case Reports, Journal Article, Video-Audio Media)
CopyrightCopyright © 2012 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Fibrinolytic Agents
  • Streptokinase
  • Adult
  • Echocardiography, Doppler, Color
  • Female
  • Fibrinolytic Agents (administration & dosage)
  • Heart Valve Prosthesis
  • Heart Valve Prosthesis Implantation (adverse effects, instrumentation)
  • Humans
  • Mitral Valve Stenosis (surgery)
  • Pregnancy
  • Pregnancy Complications, Cardiovascular (diagnosis, drug therapy, etiology)
  • Streptokinase (administration & dosage)
  • Thrombolytic Therapy
  • Thrombosis (diagnosis, drug therapy, etiology)
  • Treatment Outcome

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