The association of oxidative stress with hypertensive retinopathy.

Abstract

This study was designed to answer the following questions: (i) Do levels of serum gamma-glutamyl transferase (GGT), a marker of oxidative stress, change in hypertensive retinopathy (HR)? (ii) Is there any relation between degree of HR and GGT levels? This study included 80 hypertensive patients with HR. Group 1 comprised 40 patients with grade I HR, and group 2 comprised 40 patients with grade II HR. We selected 40 healthy subjects for the control group. Level of GGT in group 2 was significantly higher than in group 1 (P = 0.005) and control group (P = 0.001); it was also higher in group 1 than in control group (P = 0.025). Our study suggests that oxidative stress, mechanisms known to be involved in vascular lesions, may promote the development of HR.

• Authors: Mustafa Karaca, Erkan Coban, Rasih Felek, Mustafa Unal
• Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) (Clin Exp Hypertens) Vol. 35 Issue 1 Pg. 16-9 ( 2013) ISSN: 1525-6006 [Electronic] England
• PMID: 22571627 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• gamma-Glutamyltransferase

Topics

• Adult
• Biomarkers (blood)
• Blood Pressure
• Case-Control Studies
• Female
• Humans
• Hypertensive Retinopathy (blood, enzymology, etiology, physiopathology)
• Male
• Middle Aged
• Oxidative Stress
• gamma-Glutamyltransferase (blood)