Botulinum toxin injection for lower urinary tract dysfunction.

Abstract

Botulinum toxin has been recently accepted as a novel treatment for lower urinary tract dysfunctions refractory to conventional treatment. Review of the clinical trials in recent years, botulinum toxin type A has been widely used in the urethra or urinary bladder to treat voiding dysfunction due to detrusor sphincter dyssynergia, incontinence due to neurogenic or idiopathic detrusor overactivity, sensory disorders such as bladder hypersensitivity, overactive bladder, and interstitial cystitis/painful bladder syndrome. Intravesical botulinum toxin type A injection is effective in treatment of urinary incontinence due to detrusor overactivity in men and women, as well as in children. Currently botulinum toxin type A has also been applied to treat lower urinary tract symptoms due to benign prostatic hyperplasia in patients not suitable for surgery. This article reviewed the recent advances of botulinum toxin type A on lower urinary tract dysfunction.

• Authors: Yue-Chen Kuo, Hann-Chorng Kuo
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 20 Issue 1 Pg. 40-55 (Jan 2013) ISSN: 1442-2042 [Electronic] Australia
• PMID: 22571329 (Publication Type: Journal Article, Review)
• Copyright: © 2012 The Japanese Urological Association.

Chemical References

• Botulinum Toxins, Type A

Topics

• Animals
• Botulinum Toxins, Type A (therapeutic use)
• Female
• Humans
• Lower Urinary Tract Symptoms (drug therapy)
• Male
• Prostatic Hyperplasia (drug therapy)
• Urinary Bladder Diseases (drug therapy)
• Urination Disorders (drug therapy)