[Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation].

Abstract

OBJECTIVE:

To prove the clinical effect and mechanism of Bushen Huoxue Qubi Decoction on treatment of knee-osteoarthritis.

METHOD:

Ninty-six knee-osteoarthritic patients accompanied with symptoms of liver and kidney deficiency and blocked main and collateral channels were divided into two groups randomly. Patients in the treatment group (n = 48) were administrated by Bushen Huoxue Qubi Decoction one bag/day for four weeks; and those in the control group (n = 48) were given diacerein (50 mg Bid, Po) and celecoxib (0.2 Qd, Po) for four weeks. The changes of VAS score, Womac score, relative viscosity, aggregation index and IL-1beta, NO, iNOS, LPO, SOD in serum were observed. Adverse effects were determined during follow-up visit and detection for blood routine and hepatic and renal functions.

RESULT:

Its clinical control rates as per Western medicine and TCM standards for treatment of knee-osteoarthritis and effective rate were 33.3%, 37.5% and 97.9% respectively, which was remarkably higher than those in the control group (18.8%, 20.8% and 95.5%). Their difference showed statistical significance, P<0.05 or 0.01. Bushen Huoxue Qubi Decoction had an effect in obviously improving hemarheological index in 42 days and inhibiting IL-1beta, NO, iNOS and LPO better than the control group, by the contrast of 58.6% vs 47.3%, 50.1% vs 36%, 55.1% vs 41.9% and 46.7% vs 20.6% (P<0.05 or P<0.01). The treatment group also displayed a higher SOD capability the control group (2 514.71 +/- 812.65) vs (2 013.41 +/- 781.3), (P<0.01). Both groups reported no adverse effect.

CONCLUSION:

Bushen Huoxue Qubi Decoction has a better efficacy on knee-OA than traditional treatment methods (diacereinand + celecoxib) and showed no adverse effect.

• Authors: Ge Gao, Hong Wu, Jing Tian, Jinfeng Du, Xi Xie, Jiesheng Gao
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 37 Issue 3 Pg. 390-6 (Feb 2012) ISSN: 1001-5302 [Print] China
• PMID: 22568247 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Drugs, Chinese Herbal
• Interleukin-1beta
• Tumor Necrosis Factor-alpha
• bushen huoxue
• Nitric Oxide
• Nitric Oxide Synthase Type II

Topics

• Aged
• Antioxidants (adverse effects, pharmacology, therapeutic use)
• Case-Control Studies
• Drugs, Chinese Herbal (administration & dosage, adverse effects, therapeutic use)
• Female
• Hemodynamics (drug effects)
• Humans
• Interleukin-1beta (blood)
• Male
• Middle Aged
• Nitric Oxide (blood)
• Nitric Oxide Synthase Type II (blood)
• Osteoarthritis, Knee (drug therapy, metabolism)
• Treatment Outcome
• Tumor Necrosis Factor-alpha (blood)