[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].

Abstract

Cytoskeletal polymers play pleiotropic roles in neuroglial morphogenesis, intracellular transport, organization of pre- and post-synaptic scaffolds, etc. Thus, neuroglial dysfunction and degeneration are often accompanied by abnormalities in microtubules, actin and/or intermediate filament systems. Although our understanding of an unconventional cytoskeletal system composed of the septin family of GTP-binding proteins is far behind, recent studies have been revealing that qualitative and/or quantitative abnormalities of septins are also associated with neurodegenerative disorders including hereditary neuralgic amyotrophy, Parkinson disease, schizophrenia and bipolar disorder. A better understanding of the physiological and pathophysiological roles of the septin system should help develop useful biomarkers and therapeutic strategies for these diseases.

• Authors: Makoto Kinoshita
• Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology (Nihon Shinkei Seishin Yakurigaku Zasshi) Vol. 32 Issue 1 Pg. 25-9 (Feb 2012) ISSN: 1340-2544 [Print] Japan
• PMID: 22568123 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Dopamine Plasma Membrane Transport Proteins
• alpha-Synuclein
• Sept4 protein, mouse
• Septins
• Dopamine

Topics

• Animals
• Dopamine (physiology)
• Dopamine Plasma Membrane Transport Proteins
• Humans
• Mice
• Neurodegenerative Diseases (etiology)
• Parkinson Disease (etiology)
• Septins (physiology)
• Synaptic Transmission (physiology)
• alpha-Synuclein (physiology)