[Schizophrenia and carbonyl stress].

Abstract

Glyoxalase I (GLO1) is an enzyme essential for the cellular detoxification of reactive carbonyl compounds. Its impairment leads to carbonyl stress and the eventual formation of advanced glycation end products (AGEs) including pentosidine. In the present study, we provide for the first time evidence of genetic abnormalities in GLO1 with their attendant derangements of biochemistry in a small population of schizophrenia. We found that seventeen schizophrenia (approximately 17.4%) showed increases in plasma pentosidine content although they have no physical complications, and concomitantly marked decrease of pyridoxal levels was found in schizophrenia. Vitamin B6 exists in three forms, i.e., pyridoxine, pyridoxal and pyridoxamine. Pyridoxamine has potent ability to entrap RCOs and prevent their toxicity. Further study of profiling of metabolomics and clinical manifestations in schizophrenia could pave the way for novel, better therapeutic/preventive measures for this devastating disease.

• Authors: Makoto Arai, Mitsuhiro Miyashita, Tomoe Ichikawa, Masanari Itokawa
• Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica (Seishin Shinkeigaku Zasshi) Vol. 114 Issue 2 Pg. 101-7 ( 2012) ISSN: 0033-2658 [Print] Japan
• PMID: 22568112 (Publication Type: Journal Article)

Chemical References

• Glycation End Products, Advanced

Topics

• Glycation End Products, Advanced (metabolism)
• Humans
• Schizophrenia (metabolism)
• Stress, Physiological