Abstract |
Human herpesvirus-6 (HHV-6) frequently reactivates after allogeneic hematopoietic stem cell transplantation (HSCT); its most severe manifestation is the syndrome of posttransplantation acute limbic encephalitis (HHV-6-PALE). The epidemiology, risk factors, and characteristics of HHV-6-PALE after unrelated cord-blood transplantation (UCBT) are not well characterized. We analyzed 1344 patients undergoing allogeneic HSCT between March 2003 and March 2010 to identify risk factors and characteristics of HHV-6-PALE. The cohort included 1243 adult-donor HSCT and 101 UCBT recipients. All patients diagnosed with HHV-6-PALE had HHV-6 DNA in cerebrospinal fluid (CSF) specimens in addition to symptoms and studies indicating limbic encephalitis. Nineteen cases (1.4%) of HHV-6-PALE were identified during this study: 10 after UCBT (9.9%) and 9 after adult-donor HSCT (0.7%), for an incidence rate of 1.2 cases/1000 patient-days compared to 0.08 cases/1000 patient-days (P < .001), respectively. Risk factors for HHV-6-PALE on multivariable Cox modeling were UCBT (adjusted hazard ratio [aHR], 20.0; 95% confidence interval [CI], 7.3-55.0; P < .001), time-dependent acute graft-versus-host disease (aGVHD) grades II to IV (aHR, 7.5; 95% CI, 2.8-19.8; P < .001), and adult-mismatched donor (aHR, 4.3; 95% CI, 1.1-17.3; P = .04). Death from HHV-6-PALE occurred in 50% of affected patients undergoing UCBT and no recipients of adult-donor cells. Patients receiving UCBT have increased risk for HHV-6-PALE and greater morbidity from this disease.
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Authors | Joshua A Hill, Sophia Koo, Belisa B Guzman Suarez, Vincent T Ho, Corey Cutler, John Koreth, Philippe Armand, Edwin P Alyea 3rd, Lindsey R Baden, Joseph H Antin, Robert J Soiffer, Francisco M Marty |
Journal | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
(Biol Blood Marrow Transplant)
Vol. 18
Issue 11
Pg. 1638-48
(Nov 2012)
ISSN: 1523-6536 [Electronic] United States |
PMID | 22564265
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved. |
Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Analysis of Variance
- Cohort Studies
- Cord Blood Stem Cell Transplantation
(adverse effects)
- Female
- Graft vs Host Disease
(cerebrospinal fluid, etiology, immunology, virology)
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Herpesvirus 6, Human
(physiology)
- Humans
- Limbic Encephalitis
(cerebrospinal fluid, etiology, immunology, virology)
- Male
- Middle Aged
- Risk Factors
- Roseolovirus Infections
(cerebrospinal fluid, etiology, immunology, virology)
- Severity of Illness Index
- Survival Analysis
- Transplantation, Homologous
- Virus Activation
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