Abstract | BACKGROUND: OBJECTIVE: PATIENTS AND METHODS: A longitudinal retrospective case-control design was used. The medical files of 68 patients with T1D and duodenal-biopsy-confirmed CD were reviewed for data on weight, height, hemoglobin A1c (HbA1c), frequency of diabetic ketoacidosis (DKA), and severe hypoglycemic events before and after diagnosis and treatment of CD. Findings were compared with 131 patients with T1D only matched for age, gender, and duration of diabetes. RESULTS: CD was diagnosed in 5.5% of all patients with T1D attending our center during the study period; 26% of the patients with CD were symptomatic. There were no significant differences in glycemic control or frequency of severe hypoglycemia or DKA events between the study and control groups. Body mass index-standard deviation score (SDS), height-SDS, and HbA1c values were marginally but not significantly higher in the control than the study group and similar in subjects with CD with good or fair/poor adherence to a GFD throughout follow-up. CONCLUSIONS: Patients with T1D and CD treated with GFD have growth and measures of metabolic control similar to those with T1D without CD. The decision whether asymptomatic celiac patients should be put on a GFD or only symptomatic patients has to be weighed against possible short- and long-term consequences of no intervention, and should be based on more evidence from larger randomized studies.
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Authors | Irit Taler, Moshe Phillip, Yael Lebenthal, Liat de Vries, Raanan Shamir, Shlomit Shalitin |
Journal | Pediatric diabetes
(Pediatr Diabetes)
Vol. 13
Issue 8
Pg. 597-606
(Dec 2012)
ISSN: 1399-5448 [Electronic] Denmark |
PMID | 22564209
(Publication Type: Journal Article)
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Copyright | © 2012 John Wiley & Sons A/S. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Body Height
- Body Mass Index
- Case-Control Studies
- Celiac Disease
(complications, diet therapy, physiopathology)
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
(complications, physiopathology)
- Diabetic Ketoacidosis
(epidemiology)
- Diet, Gluten-Free
- Female
- Glycated Hemoglobin
(analysis)
- Growth
- Humans
- Hypoglycemia
(epidemiology)
- Longitudinal Studies
- Male
- Retrospective Studies
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