Effect of thymic hormones on induction of experimental allergic encephalomyelitis in old mice.

Abstract

This study was aimed at restoring decreased T-cell functions and reduced susceptibility to proteolipid apoprotein (PLP) induced-experimental allergic encephalomyelitis (EAE) in old mice with thymic hormones. Thymosin fraction 5 (TF-5) and serum thymic factor (FTS) had no significant in vitro and in vivo effect on proliferative responses to PLP and concanavalin A (Con A), and on EAE induction in young and old mice. These results suggest that decreased T-cell functions cannot be restored by these thymic hormones tested.

• Authors: M Endoh, T Tabira
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 161 Issue 4 Pg. 303-9 (Aug 1990) ISSN: 0040-8727 [Print] Japan
• PMID: 2256103 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apoproteins
• Myelin Proteins
• Myelin Proteolipid Protein
• Thymus Hormones
• thymosin fraction 5
• Thymosin
• Thymic Factor, Circulating

Topics

• Aging (immunology)
• Animals
• Apoproteins (immunology)
• Encephalomyelitis, Autoimmune, Experimental (etiology, immunology, prevention & control)
• Female
• In Vitro Techniques
• Lymphocyte Activation (drug effects)
• Mice
• Mice, Inbred BALB C
• Myelin Proteins (immunology)
• Myelin Proteolipid Protein
• T-Lymphocytes (drug effects, immunology)
• Thymic Factor, Circulating (pharmacology)
• Thymosin (analogs & derivatives, pharmacology)
• Thymus Hormones (pharmacology)