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Synthesis and antimicrobial activities of structurally novel S,S'-bis(heterosubstituted) disulfides.

Abstract
The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillin-resistant S. aureus and F. tularensis.
AuthorsPraveen Ramaraju, Danielle Gergeres, Edward Turos, Sonja Dickey, Daniel V Lim, John Thomas, Burt Anderson
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 22 Issue 11 Pg. 3623-31 (Jun 01 2012) ISSN: 1464-3405 [Electronic] England
PMID22560472 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Infective Agents
  • Disulfides
Topics
  • Anti-Infective Agents (chemical synthesis, chemistry, pharmacology)
  • Candida albicans (drug effects)
  • Disulfides (chemical synthesis, chemistry, pharmacology)
  • Francisella tularensis (drug effects)
  • Methicillin-Resistant Staphylococcus aureus (drug effects)
  • Microbial Sensitivity Tests
  • Structure-Activity Relationship

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