Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors.

Abstract

Dendritic cell (DC)-mediated immunotherapy has not been as effective as expected for most solid tumors. This study demonstrates immune responses against solid tumors mediated by DCs charged with photodynamic therapy (PDT)-induced tumor lysates, which contain the heat shock protein (HSP) 70. PDT tumor lysate-pulsed DC (PDT-DC) inhibited the growth of mammary EMT6 tumors to a greater extent than freeze/thawed tumor lysate-pulsed DC (FT-DC) or PDT tumor lysates. PDT-DC also showed significant anti-tumor effects against fully-established (i.e., late-stage) solid tumors. Taken together, these results suggest that PDT-DC vaccination is more effective than conventional DC therapy for the treatment of cancers.

• Authors: Nam-Chul Jung, Hee Jung Kim, Mi-Sun Kang, Jun-Ho Lee, Jie-Young Song, Han Geuk Seo, Yong-Soo Bae, Dae-Seog Lim
• Journal: Cancer letters (Cancer Lett) Vol. 324 Issue 1 Pg. 58-65 (Nov 01 2012) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 22554711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Cancer Vaccines
• HSP70 Heat-Shock Proteins
• Interleukin-2

Topics

• Animals
• Cancer Vaccines (immunology)
• Dendritic Cells (immunology)
• Female
• Freezing
• HSP70 Heat-Shock Proteins (metabolism)
• Immunotherapy (methods)
• Interleukin-2 (metabolism)
• Mammary Neoplasms, Animal (drug therapy, immunology, pathology)
• Mice
• Mice, Inbred BALB C
• Neoplasms (drug therapy, immunology, pathology)
• Photochemotherapy (methods)