Abstract | INTRODUCTION: We previously demonstrated that synovial sublining macrophages express folate receptor beta (FRβ). The aim of this study was to evaluate the efficacy of intra-articular administration of a recombinant immunotoxin to FRβ for treating rat antigen-induced arthritis. METHODS: RESULTS: Intra-articular administration of the immunotoxin attenuated joint swelling (61% suppression; P < 0.01 compared to the control on day 21) and improved histological findings, particularly cartilage and bone destruction (scores of rats treated with control versus the immunotoxin: 2.2 versus 0.5; P < 0.01), by reducing the number of FRβ-expressing macrophages and cathepsin K-positive cells. CONCLUSIONS:
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Authors | Taku Nagai, Akira Kyo, Kazuhisa Hasui, Sonshin Takao, Takami Matsuyama |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 14
Issue 3
Pg. R106
(May 02 2012)
ISSN: 1478-6362 [Electronic] England |
PMID | 22551402
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Folate Receptor 2
- Immunotoxins
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Topics |
- Animals
- Antibodies, Monoclonal
(administration & dosage, immunology)
- Antibody Specificity
- Arthritis, Rheumatoid
(drug therapy, immunology, pathology)
- Disease Models, Animal
- Female
- Folate Receptor 2
(antagonists & inhibitors, immunology)
- Immunohistochemistry
- Immunotoxins
(administration & dosage, immunology)
- Injections, Intra-Articular
- Macrophages
(immunology, metabolism)
- Mice
- Rats
- Rats, Inbred Lew
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