Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy.

Abstract

Pagetoid reticulosis or Woringer-Kolopp disease (WKD) is a rare variant of mycosis fungoides, consisting of localized patches or plaques containing intraepidermal proliferations of neoplastic T cells in a pagetoid distribution (similar to that of the adenocarcinomatous cells found in Paget disease of the nipple), which typically affects middle-aged and elderly men. We report a trial of photodynamic therapy (PDT) with topical aminolaevulinic acid (ALA), carried out on a 10-year-old boy with a solitary lesion of WKD on his foot, to avoid the long-term problems associated with the typical treatments for WKD of surgery and/or local irradiation. The plaque progressively flattened during treatment, and after nine PDT sessions over 13 months, the patient was clinically free of disease. PDT may be a viable alternative to surgery and local irradiation for localized cutaneous T-cell lymphoma, including WKD, especially in younger patients.

• Authors: G W Mendese, A Beckford, N Krejci, M Mahalingam, L Goldberg, B A Gilchrest
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 37 Issue 7 Pg. 759-61 (Oct 2012) ISSN: 1365-2230 [Electronic] England
• PMID: 22548453 (Publication Type: Case Reports, Journal Article)
• Copyright: © The Author(s). CED © 2012 British Association of Dermatologists.

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Aminolevulinic Acid (therapeutic use)
• Child
• Foot Dermatoses (drug therapy)
• Humans
• Male
• Pagetoid Reticulosis (drug therapy)
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Treatment Outcome