Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] undecane-1-yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic acid and its inhibitory effect on the cervical tumor U14 in vitro and in vivo.

Abstract

In this study, the novel germatrane compound, 3-(2, 8, 9-trioxa-5-aza-1- germatricyclo [3.3.3.0] undecane-1-yl)-3-(4-hydroxy-3- methoxyphenyl)-propionic acid (1), has been synthesized and its activities against cervical tumor U14 were evaluated in vitro and in vivo. The results have demonstrated that the compound posed significant inhibition on U14 tumor with IC(50) values of 48.57 mg/L in cell-based assay and tumor inhibitory rates of 38.50%, 47.17% and 64.02% (from low dose to high dose) in animal experiment.

• Authors: Lianbao Ye, Xiaomin Ou, Xuedong Peng, Yan Luo
• Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) (Med Chem) Vol. 8 Issue 4 Pg. 595-8 (Jul 2012) ISSN: 1875-6638 [Electronic] Netherlands
• PMID: 22548339 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3-(2,8,9-trioxa-5-aza-1-germatricyclo(3.3.3.0)undecane-1-yl)-3-(4-hydroxyl-3-methoxyphenyl)propionic acid
• Antineoplastic Agents
• Caffeic Acids
• Organometallic Compounds

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Caffeic Acids (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Female
• Inhibitory Concentration 50
• Mice
• Molecular Structure
• Organometallic Compounds (chemical synthesis, chemistry, pharmacology)
• Uterine Cervical Neoplasms (drug therapy)