Diarrhea associated with lopinavir/ritonavir-based therapy: results of a meta-analysis of 1469 HIV-1-infected participants.

Abstract

BACKGROUND:

Antiretroviral therapy is associated with adverse events (AEs). The most frequently reported AE associated with lopinavir/ritonavir (LPV/r) containing regimens is diarrhea. The objective of this meta-analysis is to describe the incidence, prevalence, and duration of diarrhea in individuals taking LPV/r.

METHODS:

This is a meta-analysis of Abbott-conducted clinical trials. Inclusion criteria included prospective randomized clinical trials with the LPV/r tablet formulation and had AE data (moderate/severe diarrhea) available through 48 weeks of treatment.

RESULTS:

Three trials (total 1469 participants) met the inclusion criteria. In all, 11.2% of participants reported moderate/severe diarrhea by week 8, with median time to resolution of 7.4 weeks. The overall 48-week incidence of moderate/severe diarrhea was 15.5%. The discontinuation rate due to moderate/severe diarrhea was 1.3%.

CONCLUSIONS:

Moderate/severe diarrhea occurred in less than 1 in 6 participants taking LPV/r, typically started in the first 8 weeks of treatment and infrequently resulted in premature discontinuation.

• Authors: Colleen M Wegzyn, Linda M Fredrick, Roxann O Stubbs, William C Woodward, Michael Norton
• Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) (J Int Assoc Physicians AIDS Care (Chic)) 2012 Jul-Aug Vol. 11 Issue 4 Pg. 252-9 ISSN: 1545-1097 [Print] United States
• PMID: 22544446 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Anti-HIV Agents
• Antidiarrheals
• Drug Combinations
• Lopinavir
• Ritonavir

Topics

• Anti-HIV Agents (adverse effects)
• Antidiarrheals (therapeutic use)
• Diarrhea (chemically induced, drug therapy, epidemiology)
• Drug Combinations
• Drug Therapy, Combination
• HIV Infections (drug therapy, virology)
• HIV-1
• Humans
• Incidence
• Lopinavir (adverse effects)
• Prevalence
• Risk Factors
• Ritonavir (adverse effects)