Metabolomic study of plasma of patients with abdominal aortic aneurysm.

Abstract

Abdominal aortic aneurysm (AAA) is an important health problem, both because of AAA rupture and death and because of increased cardiovascular mortality. Identification of new biomarkers of AAA may suggest novel pathological mechanisms and targets for new medical treatments to slow AAA progression. Metabolic changes in AAA patients were mainly related to carbohydrate and lipid metabolism and many of these changes can be associated with a situation of insulin resistance (which can be related to metabolic syndrome) together with altered amino acid metabolism. For the first time, metabolites that can be associated with differential metabolism by the gut microflora of AAA patients have also been found. Moreover, aminomalonic acid in plasma has been shown to be the metabolite with the biggest difference between patients suffering from large aneurysm (>5 cm) and controls.

• Authors: Francisco J Rupérez, Priscila Ramos-Mozo, Joanna Teul, Roxana Martinez-Pinna, Antonia Garcia, Myriam Malet-Martino, Emilio Camafeita, Juan Antonio Lopez, Carlos Pastor-Vargas, Jesús Egido, Stéphane Balayssac, Véronique Gilard, Coral Barbas, Jose Luis Martin-Ventura
• Journal: Analytical and bioanalytical chemistry (Anal Bioanal Chem) Vol. 403 Issue 6 Pg. 1651-60 (Jun 2012) ISSN: 1618-2650 [Electronic] Germany
• PMID: 22543712 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aortic Aneurysm, Abdominal (blood)
• Gas Chromatography-Mass Spectrometry
• Humans
• Magnetic Resonance Spectroscopy
• Metabolomics