Abstract | BACKGROUND: AIMS: METHODS: Ninety-five eligible patients with Crohn's disease activity index ≤150 were randomly assigned to: 6-mercaptopurine (0.5-1.5mg/kg/day, n=30); Elental as an elemental diet (≥900 kcal/day, n=32); none (control, n=33). In the three groups, patients were and remained on 5-aminosalicylic acid (2250-3000 mg/day). Patients were observed for 2 years and the rate of relapse ( Crohn's disease activity index ≥200) was monitored. RESULTS: At 24 months, the fractions of patients who had maintained remission were 60%, 46.9% and 27.2% for 6-mercaptopurine, Elental and the control groups, respectively. Log-rank test showed better efficacy for 6-mercaptopurine (P=0.0041) and Elental (P=0.0348) versus control. No significant difference was found between 6-mercaptopurine and Elental. Further, in the 6-mercaptopurine group, 2 patients experienced liver injury and one developed alopecia. CONCLUSIONS:
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Authors | Hiroyuki Hanai, Takayuki Iida, Ken Takeuchi, Hajime Arai, Osamu Arai, Jinrou Abe, Tatsuo Tanaka, Yasuhiko Maruyama, Kentarou Ikeya, Ken Sugimoto, Toshio Nakamura, Kouichi Nakamura, Fumitoshi Watanabe |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 44
Issue 8
Pg. 649-54
(Aug 2012)
ISSN: 1878-3562 [Electronic] Netherlands |
PMID | 22542605
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Immunosuppressive Agents
- Mesalamine
- Mercaptopurine
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Topics |
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Crohn Disease
(diet therapy, drug therapy)
- Food, Formulated
(adverse effects)
- Humans
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Kaplan-Meier Estimate
- Longitudinal Studies
- Maintenance Chemotherapy
- Male
- Mercaptopurine
(adverse effects, therapeutic use)
- Mesalamine
(therapeutic use)
- Recurrence
- Young Adult
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