Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care.

Anxiety disorders are frequently under-diagnosed conditions in primary care, although they can be managed effectively by general practitioners.
This paper is a short and practical summary of the World Federation of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) for the treatment in primary care. The recommendations were developed by a task force of 30 international experts in the field and are based on randomized controlled studies.
First-line pharmacological treatments for these disorders are selective serotonin reuptake inhibitors (for all disorders), serotonin-norepinephrine reuptake inhibitors (for some) and pregabalin (for generalized anxiety disorder only). A combination of medication and cognitive behavior/exposure therapy was shown to be a clinically desired treatment strategy.
This short version of an evidence-based guideline may improve treatment of anxiety disorders, OCD, and PTSD in primary care.
AuthorsBorwin Bandelow, Leo Sher, Robertas Bunevicius, Eric Hollander, Siegfried Kasper, Joseph Zohar, Hans-Jürgen Möller, ,
JournalInternational journal of psychiatry in clinical practice (Int J Psychiatry Clin Pract) Vol. 16 Issue 2 Pg. 77-84 (Jun 2012) ISSN: 1471-1788 [Electronic] England
PMID22540422 (Publication Type: Journal Article, Practice Guideline, Research Support, Non-U.S. Gov't)
Chemical References
  • Antidepressive Agents, Tricyclic
  • Antipsychotic Agents
  • Histamine Antagonists
  • Serotonin Uptake Inhibitors
  • Benzodiazepines
  • Pregabalin
  • gamma-Aminobutyric Acid
  • Antidepressive Agents, Tricyclic (therapeutic use)
  • Antipsychotic Agents (therapeutic use)
  • Anxiety Disorders (drug therapy)
  • Benzodiazepines (therapeutic use)
  • Dose-Response Relationship, Drug
  • Histamine Antagonists (therapeutic use)
  • Humans
  • Obsessive-Compulsive Disorder (drug therapy)
  • Pregabalin
  • Serotonin Uptake Inhibitors (therapeutic use)
  • Stress Disorders, Post-Traumatic (drug therapy)
  • gamma-Aminobutyric Acid (analogs & derivatives, therapeutic use)

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