Abstract |
The main use of non-ablative fractional photothermolysis today is for the improvement of wrinkles and scars. The purpose of this work was to evaluate the effect of a "classic" non-ablative fractional 1540 nm on facial photodamaged skin and actinic keratoses. Seventeen patients with facial actinic keratoses (AKs) and photodamage underwent two or three laser treatments with fractional 1540-nm erbium glass laser at fluences of 75 mJ, 15 ms pulse duration, and 10-mm spot size in non-contact mode. Two blinded assessors and participants evaluated clinical improvement of treatment areas after 3 months, using a quartile grading scale (no improvement = 0, 1-25% improvement = 1, 26-50% = 2, 51-75% = 3, and 76-100% = 4). Three months after the last treatment, the mean level of improvement was 3.4 ± 0.72 for AK and 3.3 ± 0.54 for skin appearance. Adverse events observed after each treatment were moderate erythema, mild edema, erosions (two cases), and mild desquamation. No scarring or post-inflammatory pigmentary changes were observed. The clinical results were supported by histological changes observed in Yucatan pig studies in vivo and ex vivo. The 1540-nm fractional erbium glass laser in the non-contact mode is a safe and effective treatment for facial photodamage and AKs.
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Authors | Moshe Lapidoth, Maurice Adatto, Shlomit Halachmi |
Journal | Lasers in medical science
(Lasers Med Sci)
Vol. 28
Issue 2
Pg. 537-42
(Feb 2013)
ISSN: 1435-604X [Electronic] England |
PMID | 22538843
(Publication Type: Clinical Trial, Journal Article)
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Topics |
- Aged
- Cicatrix
(pathology, surgery)
- Edema
(etiology)
- Erythema
(etiology)
- Face
(pathology, radiation effects)
- Female
- Humans
- Keratosis, Actinic
(pathology, surgery)
- Laser Therapy
(adverse effects, instrumentation, methods)
- Lasers, Solid-State
(therapeutic use)
- Male
- Middle Aged
- Scalp
(pathology, radiation effects)
- Skin
(radiation effects)
- Sunlight
(adverse effects)
- Treatment Outcome
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