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Subacute toxicity of antimicrobial peptide S-thanatin in ICR mice.

Abstract
Antibiotics are commonly used for infectious diseases and saved a lot of lives since its discovery, but the emergence of drug-resistant microorganism has brought a tremendous challenge to clinical therapy at present. Antimicrobial peptides, which are of broad antimicrobial spectrum and rare resistance development in pathogens, are expected to replace conventional antibiotics. S-thanatin, a novel antimicrobial peptide with 21 amino acid residues, was proved of significant benefit on therapy of pathogens infection. To evaluate the security of S-thanatin, its subacute toxicity was examined in ICR mice by continually intravenous injection with 125, 50, 20 mg/kg (1/4, 1/10, 1/25 LD(50)) or saline with equal volume for two weeks. Results demonstrated that neither significant difference of serum chemistry and hematology, nor pathological changes were changed in major organs caused by S-thanatin between groups. In conclusion, S-thanatin appears to be a safe antimicrobial peptide for further preclinical trials.
AuthorsGuoqiu Wu, Xuepeng Deng, Pengpeng Wu, Zilong Shen, Hanmei Xu
JournalPeptides (Peptides) Vol. 36 Issue 1 Pg. 109-13 (Jul 2012) ISSN: 1873-5169 [Electronic] United States
PMID22537943 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Infective Agents
  • Antimicrobial Cationic Peptides
  • thanatin
Topics
  • Animals
  • Anti-Infective Agents (toxicity)
  • Antimicrobial Cationic Peptides (toxicity)
  • Behavior, Animal (drug effects)
  • Female
  • Heart (drug effects)
  • Kidney (drug effects, pathology)
  • Liver (drug effects, pathology)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Myocardium (pathology)
  • Spleen (drug effects, pathology)

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