Abstract |
Antibiotics are commonly used for infectious diseases and saved a lot of lives since its discovery, but the emergence of drug-resistant microorganism has brought a tremendous challenge to clinical therapy at present. Antimicrobial peptides, which are of broad antimicrobial spectrum and rare resistance development in pathogens, are expected to replace conventional antibiotics. S-thanatin, a novel antimicrobial peptide with 21 amino acid residues, was proved of significant benefit on therapy of pathogens infection. To evaluate the security of S-thanatin, its subacute toxicity was examined in ICR mice by continually intravenous injection with 125, 50, 20 mg/kg (1/4, 1/10, 1/25 LD(50)) or saline with equal volume for two weeks. Results demonstrated that neither significant difference of serum chemistry and hematology, nor pathological changes were changed in major organs caused by S-thanatin between groups. In conclusion, S-thanatin appears to be a safe antimicrobial peptide for further preclinical trials.
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Authors | Guoqiu Wu, Xuepeng Deng, Pengpeng Wu, Zilong Shen, Hanmei Xu |
Journal | Peptides
(Peptides)
Vol. 36
Issue 1
Pg. 109-13
(Jul 2012)
ISSN: 1873-5169 [Electronic] United States |
PMID | 22537943
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Infective Agents
- Antimicrobial Cationic Peptides
- thanatin
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Topics |
- Animals
- Anti-Infective Agents
(toxicity)
- Antimicrobial Cationic Peptides
(toxicity)
- Behavior, Animal
(drug effects)
- Female
- Heart
(drug effects)
- Kidney
(drug effects, pathology)
- Liver
(drug effects, pathology)
- Male
- Mice
- Mice, Inbred ICR
- Myocardium
(pathology)
- Spleen
(drug effects, pathology)
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