[The effect of eplir on an experimental toxic lesion of the liver].

Abstract	A hepatoprotector of phospholipid nature eplir extracted from silt mud was shown to prevent like essentiale in CCl4-hepatitis in rats the development of the liver parenchyma necroses, to promote the maintenance of the normal activity of enzymes in hepatocytes, to stabilize lysosomes, to stimulate the antitoxic and excretory functions of the liver, to reduce hyperfermentemia. The mechanism of action of eplir is determined by the antioxidant properties, a decrease of lysophosphatide formation and the inclusion of phosphatidylcholine in membranes.
Authors	A S Saratikov, A I Vengerovskiĭ, O V Paul's, I M Sedykh
Journal	Farmakologiia i toksikologiia (Farmakol Toksikol) Vol. 53 Issue 5 Pg. 42-5 ( 1990) ISSN: 0014-8318 [Print] Russia (Federation)
Vernacular Title	Vliianie eplira na toksicheskoe porazhenie pecheni v éksperimente.
PMID	2253748 (Publication Type: Comparative Study, Journal Article)
Chemical References	Antioxidants Drug Combinations Phosphatidylcholines Phospholipids eplir essential 303 forte Carotenoids
Topics	Animals Antioxidants (therapeutic use) Carbon Tetrachloride Poisoning (complications, drug therapy, metabolism) Carotenoids (therapeutic use) Chemical and Drug Induced Liver Injury (drug therapy, etiology, metabolism) Drug Combinations Drug Evaluation, Preclinical Liver (drug effects, metabolism) Male Phosphatidylcholines (therapeutic use) Phospholipids (therapeutic use) Rats

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