Developmental haemostasis for factor V and factor VIII levels in neonates: a case report of spontaneous cephalhaematoma.

Abstract

Combined factor V and VIII deficiency is a rare bleeding disorder. Diagnosis of congenital coagulation factor deficiency in a neonate is challenging due to "immaturity" of the hemostatic system. A 2-day-old baby girl presented with spontaneous cephalhematoma. She was found to have persistent abnormal coagulation tests and finally diagnosed as combined factor V and VIII deficiency. Interestingly, factor V and factor VIII in developmental hemostasis are quite similar with adult levels in newborn, and hence early diagnosis is possible. An investigation to detect underlying hemostatic defects is recommended in newborns with spontaneous cephalhematoma.

• Authors: Wan Zaidah Abdullah, Rusmawati Ismail, Ariffin Nasir, Norsarwany Mohamad, Rosline Hassan
• Journal: Fetal and pediatric pathology (Fetal Pediatr Pathol) Vol. 32 Issue 2 Pg. 77-81 (Apr 2013) ISSN: 1551-3823 [Electronic] England
• PMID: 22536947 (Publication Type: Case Reports, Journal Article)

Topics

• Blood Coagulation Tests
• Factor V Deficiency (complications)
• Factor VII Deficiency (complications)
• Female
• Hematoma, Epidural, Cranial (etiology)
• Humans
• Infant, Newborn
• Infant, Newborn, Diseases