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Strategies for the treatment of antipsychotic-induced sexual dysfunction and/or hyperprolactinemia among patients of the schizophrenia spectrum: a review.

Abstract
There is limited evidence for the management of sexual dysfunction and/or hyperprolactinemia resulting from use of antipsychotics in patients with schizophrenia and spectrum. The aim of this study was to review and describe the strategies for the treatment of antipsychotic-induced sexual dysfunctions and/or hyperprolactinemia. The research was carried out through Medline/PubMed, Cochrane, Lilacs, Embase, and PsycINFO, and it included open labels or randomized clinical trials. The authors found 31 studies: 25 open-label noncontrolled studies and 6 randomized controlled clinical trials. The randomized, double-blind controlled studies that were conducted with adjunctive treatment that showed improvement of sexual dysfunction and/or decrease of prolactin levels were sildenafil and aripiprazole. The medication selegiline and cyproheptadine did not improve sexual function. The switch to quetiapine was demonstrated in 2 randomized controlled studies: 1 showed improvement in the primary outcome and the other did not. This reviewed data have suggested that further well-designed randomized controlled trials are needed to provide evidence for the effects of different strategies to manage sexual dysfunction and/or hyperprolactinaemia resulting from antipsychotics. These trials are necessary in order to have a better compliance and reduce the distress among patients with schizophrenia.
AuthorsLuciana Vargas Alves Nunes, Hugo Cogo Moreira, Denise Razzouk, Sandra Odebrecht Vargas Nunes, Jair De Jesus Mari
JournalJournal of sex & marital therapy (J Sex Marital Ther) Vol. 38 Issue 3 Pg. 281-301 ( 2012) ISSN: 1521-0715 [Electronic] England
PMID22533871 (Publication Type: Journal Article, Review)
Chemical References
  • Antipsychotic Agents
  • Piperazines
  • Purines
  • Quinolones
  • Sulfones
  • Vasodilator Agents
  • Aripiprazole
  • Sildenafil Citrate
Topics
  • Adult
  • Antipsychotic Agents (adverse effects, therapeutic use)
  • Aripiprazole
  • Drug Substitution
  • Drug Therapy, Combination
  • Erectile Dysfunction (chemically induced, drug therapy, prevention & control)
  • Female
  • Humans
  • Hyperprolactinemia (chemically induced, prevention & control)
  • Male
  • Piperazines (administration & dosage, therapeutic use)
  • Psychotic Disorders (drug therapy, psychology)
  • Purines (administration & dosage)
  • Quinolones (therapeutic use)
  • Schizophrenia (drug therapy)
  • Schizophrenic Psychology
  • Sexual Dysfunction, Physiological (chemically induced, drug therapy, prevention & control)
  • Sildenafil Citrate
  • Sulfones (administration & dosage)
  • Vasodilator Agents (administration & dosage)

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