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Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment.

AuthorsClarence T T Wong, Dewi K Rowlands, Chi-Hang Wong, Theodore W C Lo, Giang K T Nguyen, Hoi-Yeung Li, James P Tam
JournalAngewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 51 Issue 23 Pg. 5620-4 (Jun 04 2012) ISSN: 1521-3773 [Electronic] Germany
PMID22532483 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bradykinin B1 Receptor Antagonists
  • Cyclotides
  • Receptor, Bradykinin B1
Topics
  • Administration, Oral
  • Amino Acid Sequence
  • Animals
  • Apoptosis (drug effects)
  • Bradykinin B1 Receptor Antagonists
  • Cyclotides (chemistry, therapeutic use, toxicity)
  • HeLa Cells
  • Humans
  • Mice
  • Mice, Knockout
  • NIH 3T3 Cells
  • Pain (drug therapy)
  • Protein Engineering
  • Protein Stability
  • Receptor, Bradykinin B1 (metabolism)

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