Effects of some endocrine disruptors on cell cycle progression and murine dendritic cell differentiation.

Abstract

Endocrine disruptor chemicals (EDCs), which are predominantly present in the environment, are able to mimic or antagonise the biological activity of hormones primarily through the interaction with specific receptors. The main consequences are adverse effects on the growth and development of reproductive organs, the induction of cancer and effects on neuronal differentiation. In this study, we investigated the ability of certain EDCs, Bisphenol A (BPA), Bisphenol B (BPB), Bisphenol F (BPF), 4-n Nonylphenol (NP) and Octylphenol (OP), belonging to a homogeneous group of phenol origin, to interfere with specific cellular processes, namely, proliferation, by using MCF-7 breast carcinoma cells, and differentiation, by using murine bone marrow dendritic cells. We correlated the data on cell growth with the stimulation of cell cycle progression, which could become a step in the development of cancer, and we established a proliferation ranking between the tested EDCs: NP>BPA>OP>BPB>BPF. In addition, we investigated the ability of NP, BPA and OP to induce the differentiation of dendritic cells, the powerful antigen-presenting cells of the immune system. The differentiation and activation of these cells could affect a well-regulated immune response and determine an allergic sensitisation. We found that BPA and NP were active in determining differentiation.

• Authors: L Pisapia, G Del Pozzo, P Barba, L Caputo, L Mita, E Viggiano, G L Russo, C Nicolucci, S Rossi, U Bencivenga, D G Mita, N Diano
• Journal: General and comparative endocrinology (Gen Comp Endocrinol) Vol. 178 Issue 1 Pg. 54-63 (Aug 01 2012) ISSN: 1095-6840 [Electronic] United States
• PMID: 22531466 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Benzhydryl Compounds
• Endocrine Disruptors
• Phenols
• octylphenol
• bisphenol B
• 4-nonylphenol
• bisphenol A

Topics

• Animals
• Benzhydryl Compounds
• Cell Cycle (drug effects)
• Cell Differentiation (drug effects)
• Cell Line, Tumor
• Cells, Cultured
• Dendritic Cells (cytology, drug effects)
• Endocrine Disruptors (pharmacology)
• Female
• Humans
• Mice
• Mice, Inbred C57BL
• Phenols (pharmacology)