Pressure-induced angioedema associated with endotracheal tube: successful treatment with epinephrine in two cases.

Abstract

UNLABELLED:

Pressure-induced urticaria is a non-immunoglobulin E-mediated type of urticaria. Some patients only have angioedema, and the term pressure-induced angioedema (PIA) is more appropriate for them. PIA has not previously been reported in association with endotracheal tube. Here we describe two patients who developed PIA after endotracheal intubation. There were no histories of angioedema, drug and food allergy in both patients. Tests for specific aero-allergens and latex were negative. Serum total immunoglobulin E and C4 levels were in normal ranges. Antihistamines and intravenous steroid therapy were ineffective. Angioedema regressed with intravenous epinephrine infusion and did not relapse after extubation.

CONCLUSION:

We suggest that endotracheal tubes can cause PIA. Epinephrine therapy should be used early at treatment, especially in the patients who are at great risk for life-threatening airway problems.

• Authors: Cağlar Odek, Tanıl Kendirli, Funda Cipe, Banu Katlan, Figen Doğu
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 171 Issue 10 Pg. 1573-5 (Oct 2012) ISSN: 1432-1076 [Electronic] Germany
• PMID: 22527569 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vasoconstrictor Agents
• Epinephrine

Topics

• Angioedema (drug therapy, etiology)
• Child, Preschool
• Epinephrine (therapeutic use)
• Humans
• Intubation, Intratracheal (adverse effects)
• Male
• Vasoconstrictor Agents (therapeutic use)