Abstract | OBJECTIVE: The expression of 2-amino-3-(5-methyl-3-oxo-1, 2-oxazol-4-yl) propanoic acid receptor (AMPAR) subunits in the hippocampus of naive immature and adult rats (IRs, ARs) was investigated after status convulsion (SC). METHODS: RESULTS: Severe seizures induced neuronal apoptosis in the hippocampus. The proportion of apoptotic cells in IRs was consistently lower than that in ARs after SC. The expressions of four AMPAR subunits in IRs were consistently lower than those in ARs before and after SC. SC for 1 h inhibited the expression of glutamate receptors (GluR1-4) in the hippocampus of IRs and ARs and altered the subunit composition of AMPARs. GluR2 was the predominant AMPAR subunit in the hippocampus of normal ARs, while the GluR2/3 subunits were predominantly expressed 7 days after SC. GluR3/4 subunits were mainly expressed in the hippocampus of normal IRs, which had the lowest levels of GluR2. CONCLUSIONS: Immature brain was more resistant to seizure-induced neural damage. The time course of reduction and recovery differed for each subunit and was dependent on developmental stage. The increased expression of GluR2 could confer early but transient protection in the immature brain after SC.
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Authors | Yue Hu, Li Jiang, Hengsheng Chen, XiaoPing Zhang |
Journal | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
(Childs Nerv Syst)
Vol. 28
Issue 6
Pg. 911-8
(Jun 2012)
ISSN: 1433-0350 [Electronic] Germany |
PMID | 22526441
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Convulsants
- Receptors, AMPA
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Topics |
- Age Factors
- Aging
(physiology)
- Animals
- Apoptosis
(physiology)
- Blotting, Western
- Convulsants
(toxicity)
- Disease Models, Animal
- Hippocampus
(metabolism)
- In Situ Nick-End Labeling
- Rats
- Rats, Wistar
- Receptors, AMPA
(biosynthesis)
- Status Epilepticus
(complications, metabolism, pathology)
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