Vitamin D in kidney disease: pathophysiology and the utility of treatment.

Abstract

CKD is associated with decreased vitamin D metabolites, both the storage form 25(OH)D and the active form 1,25-dihydroxyvitamin D. This contributes to hyperparathyroidism, and increased levels of PTH mobilize minerals from the skeleton and increase the risk for fractures. Treatment with vitamin D sterols efficiently reduces secondary hyperparathyroidism of CKD. Observational studies suggest survival and other potential benefits of vitamin D treatment in the CKD population. These observations need to be verified with controlled prospective trials.

• Authors: Rizwan A Qazi, Kevin J Martin
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 38 Issue 1 Pg. 115-23 (Feb 2012) ISSN: 1558-3163 [Electronic] United States
• PMID: 22525847 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.