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Management of ovarian and testicular sex cord-stromal tumors in children and adolescents.

Abstract
Pediatric ovarian and testicular sex cord-stromal tumors are distinct from germ cell neoplasms and may present with palpable mass or signs of hormone production. Both may be associated with specific genetic syndromes. Staging for ovarian sex cord-stromal tumors is based on the International Federation of Gynecology and Obstetrics classification for ovarian carcinoma. Treatment for those with high risk disease includes multiagent chemotherapy. Testicular stromal tumors often, though not always, follow a benign course. Additional research will help to define optimal treatment strategies for children with these rare tumors.
AuthorsKris Ann P Schultz, Dominik T Schneider, Farzana Pashankar, Jonathan Ross, Lindsay Frazier
JournalJournal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 34 Suppl 2 Pg. S55-63 (May 2012) ISSN: 1536-3678 [Electronic] United States
PMID22525408 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Neoplasm Staging
  • Ovarian Neoplasms (epidemiology, pathology, therapy)
  • Risk Factors
  • Sex Cord-Gonadal Stromal Tumors (epidemiology, pathology, therapy)
  • Testicular Neoplasms (epidemiology, pathology, therapy)

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