Abstract | BACKGROUND AND OBJECTIVE: METHODS: RESULTS: Treg frequencies in peripheral blood were significantly higher in patients with TBDM, TB and TBP than in the control group, with the frequency in TBDM being the highest (P < 0.01 for all). In TBP patients, Treg frequencies were significantly lower in pleural effusions than in peripheral blood. In TB patients, Treg frequencies in BALF and peripheral blood were not significantly different. However, in TBDM patients, Treg frequencies were significantly higher in BALF than in peripheral blood. IL-10 expression was significantly higher, and IFN-γ expression was significantly lower in BALF of TBDM patients compared with BALF and pleural effusions of TB patients. CONCLUSIONS: In patients with pulmonary tuberculosis and DM, the imbalance between Treg and effector T-cells at pathological sites may be associated with weakened immunity and clinical manifestations of TB.
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Authors | Qin Sun, Qing Zhang, Heping Xiao, Haiyan Cui, Bo Su |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 17
Issue 5
Pg. 876-82
(Jul 2012)
ISSN: 1440-1843 [Electronic] Australia |
PMID | 22524702
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
Chemical References |
- Interleukin-2 Receptor alpha Subunit
- Interleukin-7 Receptor alpha Subunit
- Interleukin-10
- Interferon-gamma
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Topics |
- Adult
- Aged
- Blood Cells
(pathology)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Case-Control Studies
- Cell Communication
(physiology)
- Comorbidity
- Diabetes Mellitus
(epidemiology, metabolism, pathology)
- Female
- Humans
- Immune System
(physiopathology)
- Interferon-gamma
(analysis)
- Interleukin-10
(analysis)
- Interleukin-2 Receptor alpha Subunit
(metabolism)
- Interleukin-7 Receptor alpha Subunit
(metabolism)
- Male
- Middle Aged
- T-Lymphocyte Subsets
(pathology)
- T-Lymphocytes, Regulatory
(immunology, pathology)
- Tuberculosis, Pulmonary
(epidemiology, metabolism, pathology)
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