HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Topical measles-mumps-rubella vaccine in the treatment of recurrent respiratory papillomatosis: results of a preliminary randomized, controlled trial.

Abstract
We conducted a study to test the hypothesis that the measles-mumps-rubella (MMR) vaccine can either prevent further recurrences of recurrent respiratory papillomatosis (RRP) or prolong its remission. Our study population was made up of 26 children with RRP. All patients underwent surgical excision of their lesions. After the lesions were removed, half of these patients were prospectively randomized to receive a topical coating of the MMR vaccine on the site of their excised lesion (intervention group); the other half were treated with excision alone (control group). The patients in the intervention group experienced a longer period of recurrence-free remission than did those in the control group (median: 160 and 133 days, respectively), but the difference was not statistically significant. Therefore, it appears that topical MMR vaccine as an adjunct to routine surgical management may not be beneficial in preventing or slowing the return of RRP. However, we believe that further studies with larger patient populations are warranted.
AuthorsJin Lei, Wang Yu, Lin Yuexin, Chen Qi, Sun Xiumin, Zhang Tianyu
JournalEar, nose, & throat journal (Ear Nose Throat J) Vol. 91 Issue 4 Pg. 174-5 (Apr 2012) ISSN: 1942-7522 [Electronic] United States
PMID22522357 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Measles-Mumps-Rubella Vaccine
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Chronic Disease
  • Disease Progression
  • Female
  • Humans
  • Infant
  • Kaplan-Meier Estimate
  • Laryngeal Diseases (prevention & control, surgery)
  • Larynx (pathology)
  • Male
  • Measles-Mumps-Rubella Vaccine
  • Papillomavirus Infections (immunology, prevention & control, surgery)
  • Recurrence
  • Respiratory Tract Infections (immunology, prevention & control, surgery)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: