Effects of various drug therapies on Kleine-Levin syndrome: a case report.

Abstract

Kleine-Levin syndrome (KLS) is a rare sleep disorder, predominantly affecting adolescent males, which presents as recurrent episodes of hypersomnia, behavioral and cognitive disturbances, hyperphagia and sometimes hypersexuality (Lisk, "Kleine-Levin syndrome." Pract Neurol 2009;9:42-45). Modafinil has been reported to show an effect in shortening the duration of symptomatic periods, but does not affect the recurrence rate (Huang et al., "Kleine-Levin syndrome: current status." Med Clin N Am 2010;94:557-562). However, no single drug therapy has been consistently successful, despite various psychotropic agents, including lithium, anticonvulsants and antidepressants, having been systematically tried (Arnulf et al., "Kleine-Levin syndrome: a systematic study of 108 patients." Ann Neurol 2008;63:482-492). This study reports a male adolescent with KLS who received several courses of drug therapy, providing a chance to compare differential drug effects over time.

• Authors: Chi-Chun Yao, Ying Lin, Hui-Ching Liu, Chau-Shoun Lee
• Journal: General hospital psychiatry (Gen Hosp Psychiatry) 2013 Jan-Feb Vol. 35 Issue 1 Pg. 102.e7-9 ISSN: 1873-7714 [Electronic] United States
• PMID: 22520717 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Anticonvulsants
• Antimanic Agents
• Lithium Compounds
• Carbamazepine
• Valproic Acid
• Lorazepam
• Oxcarbazepine

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Anticonvulsants (therapeutic use)
• Antimanic Agents (therapeutic use)
• Carbamazepine (analogs & derivatives, therapeutic use)
• Cerebral Cortex (physiopathology)
• Electroencephalography
• Humans
• Kleine-Levin Syndrome (drug therapy, physiopathology)
• Lithium Compounds (therapeutic use)
• Lorazepam (therapeutic use)
• Male
• Oxcarbazepine
• Pulse Therapy, Drug
• Valproic Acid (therapeutic use)