Abstract | BACKGROUND:
Vasopressin is known to be an effective vasopressor in the treatment of septic shock, but uncertainty remains about its effect on other hemodynamic parameters. METHODS: RESULTS: Equal BPs were maintained in both treatment groups, with a significant reduction in norepinephrine requirements in the patients treated with vasopressin. The major hemodynamic difference between the two groups was a significant reduction in heart rate in the patients treated with vasopressin (P <.0001), and this was most pronounced in the less severe shock stratum (treatment × shock stratum interaction, P =.03). There were no other major cardiopulmonary differences between treatment groups, including no difference in cardiac index or stroke volume index between patients treated with vasopressin and those treated with norepinephrine. There was significantly greater use of inotropic drugs in the vasopressin group than in the norepinephrine group. CONCLUSIONS:
Vasopressin treatment in septic shock is associated with a significant reduction in heart rate but no change in cardiac output or other measures of perfusion. TRIAL REGISTRY: ISRCTN Register; No.: ISRCTN94845869; URL: www.isrctn.org
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Authors | Anthony C Gordon, Nan Wang, Keith R Walley, Deborah Ashby, James A Russell |
Journal | Chest
(Chest)
Vol. 142
Issue 3
Pg. 593-605
(Sep 2012)
ISSN: 1931-3543 [Electronic] United States |
PMID | 22518026
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasoconstrictor Agents
- Vasopressins
- Norepinephrine
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Topics |
- Adult
- Aged
- Blood Pressure
(drug effects, physiology)
- Cardiac Output
(drug effects, physiology)
- Cardiovascular System
(drug effects, physiopathology)
- Double-Blind Method
- Female
- Heart Rate
(drug effects, physiology)
- Hemodynamics
(drug effects, physiology)
- Humans
- Male
- Middle Aged
- Norepinephrine
(pharmacology, therapeutic use)
- Severity of Illness Index
- Shock, Septic
(drug therapy, physiopathology)
- Stroke Volume
(drug effects, physiology)
- Vasoconstrictor Agents
(pharmacology, therapeutic use)
- Vasopressins
(pharmacology, therapeutic use)
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