[Ultrasound guided implantation of radioactive (125)I seeds for treatment of recurrent head and neck carcinomas].

Abstract

OBJECTIVE:

To evaluate the efficacy and the technological feasibility of B-ultrasound guided implantation of (125)I seed for recurrent head and neck cancer.

METHODS:

In the study, 29 patients with local or regional recurrence of head and neck tumors after external beam radiotherapy alone, external beam radiotherapy combined neck dissection or chemotherapy were treated with (125)I seed implantation guided by ultrasound under local anesthesia. The median number of seeds was 27 (ranging from 3 to 61), and the radioactive activity ranged from 0.35-0.8 mCi(1.30×10(7) -2.96×10(7) Bq). Postoperative quality evaluations were routinely obtained for all the patients.

RESULTS:

The median follow-up was 8 months (ranging from 3 to 42 months). The 1-, 2- and 3-year local controls were 53.1%, 34.8%, and 17.4%, respectively. The 1-, 2- and 3-year survival rates were 54.1%, 27.5%, and 27.5%, respectively.

CONCLUSION:

Ultrasound guided implantation of (125)I seeds can play an important role in the salvage treatment of recurrence of head and neck cancer. This study shows B-ultrasound guided (125)I seed implantation is one of the most efficient brachytherapies, which is easy to operate, least invasive and safe for low morbidity.

• Authors: Ping Jiang, Yue Ma, Jun-jie Wang, Wei-qiang Ran, Yu Liang Jiang, Ang Qu
• Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao Yi Xue Ban) Vol. 44 Issue 2 Pg. 291-4 (Apr 18 2012) ISSN: 1671-167X [Print] China
• PMID: 22517006 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes

Topics

• Adult
• Aged
• Aged, 80 and over
• Brachytherapy (methods)
• Carcinoma, Squamous Cell (diagnostic imaging, radiotherapy)
• Female
• Head and Neck Neoplasms (diagnostic imaging, radiotherapy)
• Humans
• Iodine Radioisotopes (administration & dosage)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnostic imaging, radiotherapy)
• Radiotherapy, Image-Guided (methods)
• Ultrasonography (methods)
• Young Adult