Abstract |
The administration of amphotericin B (AmB) is often limited by the development of nephrotoxicity. In a pilot crossover trial, aqueous AmB followed by a new preparation of a mixture of AmB with 20% intralipid (AmB-IL) was administered to 10 immunocompromised patients for systemic fungal infections caused by Candida species. Mean total dose and duration of therapy with AmB-IL exceeded that of aqueous AmB (649±165 mg versus 394±105 mg, P=0.061 and 13.2±2.5 days versus 9±2.1 days, P=0.31). However, mean creatinine clearance of the patients rose during AmB-IL therapy by 10.7±7.7 mL/min (P=0.03). AmB-IL warrants further investigation to assess its stability and efficacy for treating serious fungal infections.
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Authors | S Salama, C Rotstein |
Journal | The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
(Can J Infect Dis)
Vol. 8
Issue 3
Pg. 157-60
(May 1997)
ISSN: 1180-2332 [Print] Canada |
PMID | 22514488
(Publication Type: Journal Article)
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