[The preparation of paeonol transdermal delivery systems based on the microemulsion-based gels and its pharmacokinetics characters].
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| Abstract |
Investigation of the pharmacokinetics of paeonol microemulsion, microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/MS is reported in this study. The microdialysis systems were established by linear probes and concentric circles probes. In vivo recovery of paeonol in skin is (69.7 +/- 4.8) % and in blood is (51.6 +/- 7.2)%. The paeonol microemulsion, microemulsion-based gels and marketed paeonol ointments were administered to rats. PBS (pH 7.4) served as perfused solution. The perfusion rate was 5 microL x mL(-1) and the microdialysis samples were collected every 20 min intervals. The paeonol concentration in perfused solution was determined by LC/MS. The results showed that paeonol microemulsion and microemulsion-based gels significantly raised the drug concentrations in skin more than that of paeonol ointments. The paeonol microemulsion-based gels has similar bioavailability as the paeonol ointments in blood, but its blood drug concentrations were steadier. The paeonol microemulsion-based gels may be developed into a new preparation for dermis eczema. The skin-blood synchronous microdialysis technique proved to be a new method for the pharmacokinetics study of transdermal delivery systems.
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| Authors | Ji-Yong Liu, Ying Han, Jin-Hong Hu, Zheng-Tao Wang, Kai-Xian Chen |
| Journal | Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 47 Issue 2 Pg. 244-9 (Feb 2012) ISSN: 0513-4870 [Print] China |
| PMID | 22512039 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't) |
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