The use and tolerability of Crotalidae Polyvalent Immune FAB (Ovine) in pediatric envenomations.

There are limited data on the use of Crotalidae Polyvalent Immune FAB-Ovine (CroFab) in the management of crotalid envenomations in children. Thus, the primary objective of this retrospective chart review was to evaluate the safety and tolerability of CroFab in a pediatric population. Over an 8-year time period at this institution, there were 204 admissions for snakebite of which 82 received CroFab. Children who received CroFab were more often associated with bites to the hands and fingers and tended to have more significant envenomations as indicated by longer hospital stays, greater tissue injury, and a tendency to require surgery more often. Six (7.3%) of the 82 patients who received CroFab experienced an adverse drug reaction. Reactions consisted of allergic symptoms that were mild, responded to minimal interventions, and did not limit the subsequent use of CroFab. It is concluded that CroFab use is typically well tolerated in pediatric patients.
AuthorsHenry C Farrar, Taylor Grayham, Branson Bolden, Dileep Vyas, James Graham, Laura P James
JournalClinical pediatrics (Clin Pediatr (Phila)) Vol. 51 Issue 10 Pg. 945-9 (Oct 2012) ISSN: 1938-2707 [Electronic] United States
PMID22511193 (Publication Type: Evaluation Studies, Journal Article)
Chemical References
  • Antivenins
  • Crotalid Venoms
  • Crotalidae Polyvalent immune Fab
  • Immunoglobulin Fab Fragments
  • Immunoglobulin Fragments
  • Animals
  • Antivenins (adverse effects, therapeutic use)
  • Child
  • Child, Preschool
  • Crotalid Venoms (antagonists & inhibitors)
  • Female
  • Humans
  • Hypersensitivity (epidemiology, etiology)
  • Immunoglobulin Fab Fragments
  • Immunoglobulin Fragments (adverse effects, therapeutic use)
  • Incidence
  • Male
  • Retrospective Studies
  • Severity of Illness Index
  • Snake Bites (therapy)
  • Treatment Outcome
  • Viperidae

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: