Abstract | PURPOSE: EXPERIMENTAL DESIGN: Patients with treatment-refractory advanced solid tumors were sequentially enrolled at 2 ganitumab dose levels (6 or 12 mg/kg i.v. every 2 weeks) combined with either sorafenib 400 mg twice daily, panitumumab 6 mg/kg every 2 weeks, erlotinib 150 mg once daily, or gemcitabine 1,000 mg/m(2) on days 1, 8, and 15 of each 4-week cycle. The primary end points were safety and pharmacokinetics of ganitumab. RESULTS: CONCLUSIONS:
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Authors | Lee S Rosen, Igor Puzanov, Gregory Friberg, Emily Chan, Yuying C Hwang, Hongjie Deng, Jill Gilbert, Devalingam Mahalingam, Ian McCaffery, Shaunita A Michael, Alain C Mita, Monica M Mita, Marilyn Mulay, Poornima Shubhakar, Min Zhu, John Sarantopoulos |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 18
Issue 12
Pg. 3414-27
(Jun 15 2012)
ISSN: 1557-3265 [Electronic] United States |
PMID | 22510349
(Publication Type: Clinical Trial, Phase I, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | ©2012 AACR. |
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Benzenesulfonates
- Biomarkers, Tumor
- Phenylurea Compounds
- Pyridines
- Quinazolines
- Deoxycytidine
- Niacinamide
- Panitumumab
- Sorafenib
- ganitumab
- Erlotinib Hydrochloride
- Receptor, IGF Type 1
- Gemcitabine
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Topics |
- Adult
- Aged
- Antibodies, Monoclonal
(administration & dosage, adverse effects, pharmacokinetics)
- Antibodies, Monoclonal, Humanized
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Benzenesulfonates
(administration & dosage, adverse effects)
- Biomarkers, Tumor
- Deoxycytidine
(administration & dosage, adverse effects, analogs & derivatives)
- Erlotinib Hydrochloride
- Female
- Humans
- Male
- Middle Aged
- Neoplasms
(drug therapy)
- Niacinamide
(analogs & derivatives)
- Panitumumab
- Phenylurea Compounds
- Pyridines
(administration & dosage, adverse effects)
- Quinazolines
(administration & dosage, adverse effects, therapeutic use)
- Receptor, IGF Type 1
(antagonists & inhibitors)
- Sorafenib
- Gemcitabine
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