PDGF and PDGF receptors in glioma.

Abstract

The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in normal embryonic development, cellular differentiation, and response to tissue damage. Not surprisingly, as it is a multi-faceted regulatory system, numerous pathological conditions are associated with aberrant activity of the PDGFs and their receptors. As we and others have shown, human gliomas, especially glioblastoma, express all PDGF ligands and both the two cell surface receptors, PDGFR-α and -β. The cellular distribution of these proteins in tumors indicates that glial tumor cells are stimulated via PDGF/PDGFR-α autocrine and paracrine loops, while tumor vessels are stimulated via the PDGFR-β. Here we summarize the initial discoveries on the role of PDGF and PDGF receptors in gliomas and provide a brief overview of what is known in this field.

• Authors: Inga Nazarenko, Sanna-Maria Hede, Xiaobing He, Anna Hedrén, James Thompson, Mikael S Lindström, Monica Nistér
• Journal: Upsala journal of medical sciences (Ups J Med Sci) Vol. 117 Issue 2 Pg. 99-112 (May 2012) ISSN: 2000-1967 [Electronic] Sweden
• PMID: 22509804 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Platelet-Derived Growth Factor
• Receptors, Platelet-Derived Growth Factor

Topics

• Brain Neoplasms (physiopathology)
• Central Nervous System (physiology)
• Glioma (physiopathology)
• Humans
• Platelet-Derived Growth Factor (physiology)
• Receptors, Platelet-Derived Growth Factor (physiology)