Abstract | BACKGROUND: METHODOLOGY/PRINCIPAL FINDINGS: Genetic polymorphisms of NFKB1 and NFKBIA were analyzed by a real-time polymerase chain reaction (real-time PCR) for 462 patients with oral cancer and 520 non- cancer controls. We found that NFKB1 -94 ATGG1/ATGG2, -94 ATGG2/ATGG2, and the combination of -94 ATGG1/ATGG2 and ATGG2/ATGG2 genotypes NFKBIA -826 T (CT+TT) and -881 G (AG+GG) allelic carriages, were more prevalent in OSCC patients than in non- cancer participants. Moreover, we found that NFKB1 or NFKBIA gene polymorphisms seem to be related to susceptibility to develop oral cancer linked to betel nut and tobacco consumption. Finally, patients with oral cancer who had at least one -519 T allele of the NFKBIA gene were at higher risk for developing distant metastasis (P<.05), compared with those patients CC homozygotes. CONCLUSIONS: Our results suggest that NFKB1 -94 ATTG2, NFKBIA -826 T, and -881 G alleles are associated with oral carcinogenesis. The combination of NFKB1 or NFKBIA gene polymorphisms and environmental carcinogens appears related to an increased risk of oral cancer. More importantly, the genetic polymorphism of NFKBIA -519 might be a predictive factor for the distal metastasis of OSCC in Taiwanese.
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Authors | Chiao-Wen Lin, Yih-Shou Hsieh, Chung-Han Hsin, Chun-Wen Su, Chien-Huang Lin, Lin-Hung Wei, Shun-Fa Yang, Ming-Hsien Chien |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 4
Pg. e35078
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 22509384
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- I-kappa B Proteins
- NF-kappa B p50 Subunit
- NFKB1 protein, human
- NFKBIA protein, human
- NF-KappaB Inhibitor alpha
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Topics |
- Adult
- Aged
- Alcohol Drinking
(adverse effects)
- Areca
(adverse effects)
- Asian People
- Carcinoma, Squamous Cell
(genetics, pathology)
- Disease Susceptibility
- Female
- Genetic Association Studies
- Humans
- I-kappa B Proteins
(genetics)
- Male
- Middle Aged
- Mouth Neoplasms
(genetics, pathology)
- NF-KappaB Inhibitor alpha
- NF-kappa B p50 Subunit
(genetics)
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Smoking
(adverse effects)
- Taiwan
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