Abstract | OBJECTIVE: To study the inhibitory effect of Luteolin on LPS-induced BV-2 cell. METHODS: RESULTS:
Luteolin significantly decreased the NO production and TLR4 protein expression as well as iNOS activity in LPS-activated microglial cell. CONCLUSION: LPS induced activation of microglia lead to inflammatory response and its mechanism may be related to inhibiting TLR4 signaling pathway.
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Authors | Feng Huang, Miao-Miao Zhu, Hua-Ming Deng, Zai-Jun Zhang, Li Yang, Fei Xiao, Ying Xiao, Hong Nie |
Journal | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
(Zhong Yao Cai)
Vol. 34
Issue 11
Pg. 1746-9
(Nov 2011)
ISSN: 1001-4454 [Print] China |
PMID | 22506402
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Lipopolysaccharides
- Toll-Like Receptor 4
- Nitric Oxide
- Nitric Oxide Synthase
- Luteolin
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Blotting, Western
- Cell Line
- Cell Survival
(drug effects)
- Enzyme Activation
(drug effects)
- Gene Expression Regulation, Enzymologic
(drug effects)
- Inflammation
(chemically induced, metabolism, prevention & control)
- Lipopolysaccharides
(administration & dosage, pharmacology)
- Luteolin
(pharmacology)
- Mice
- Microglia
(drug effects, metabolism, pathology)
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase
(metabolism)
- Signal Transduction
(drug effects)
- Toll-Like Receptor 4
(metabolism)
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