Carcinogenic effect of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a postulated proximate pancreatic carcinogen in Syrian hamsters.

Abstract

N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular adenocarcinomas than did N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine, and these neoplasms showed a great tendency for invasion and metastasis. Also, HPOP induced tumors of the forestomach, liver, gallbladder, kidneys, and vagina (as did BOP). However, HPOP [unlike BOP, but like N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine] led to tumor development in the nasal cavity, larynx, trachea, intestine, Harderian gland, lips, and flank organ. The possible mechanisms of HPOP carcinogenicity are discussed.

• Authors: P Pour, L Wallcave, R Gingell, D Nagel, T Lawson, S Salmasi, S Tines
• Journal: Cancer research (Cancer Res) Vol. 39 Issue 10 Pg. 3828-33 (Oct 1979) ISSN: 0008-5472 [Print] United States
• PMID: 225009 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Nitrosamines
• N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine

Topics

• Animals
• Biotransformation
• Carcinogens
• Carcinoma, Intraductal, Noninfiltrating (chemically induced)
• Cricetinae
• Digestive System Neoplasms (chemically induced)
• Female
• Male
• Mesocricetus
• Neoplasms, Experimental (chemically induced, pathology)
• Nitrosamines (metabolism, toxicity)
• Pancreas (metabolism)
• Pancreatic Neoplasms (chemically induced)
• Respiratory Tract Neoplasms (chemically induced)
• Urogenital Neoplasms (chemically induced)