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Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.

AbstractBACKGROUND:
We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes.
METHODOLOGY/PRINCIPAL FINDINGS:
We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet.
CONCLUSIONS/SIGNIFICANCE:
These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes.
AuthorsHirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, Toshinari Takamura
JournalPloS one (PLoS One) Vol. 7 Issue 4 Pg. e34952 ( 2012) ISSN: 1932-6203 [Electronic] United States
PMID22496878 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • ADIPOQ protein, human
  • Adiponectin
  • Blood Glucose
  • Dietary Sucrose
  • Insulin
  • Selenoprotein P
Topics
  • Adiponectin (blood)
  • Aged
  • Animals
  • Blood Glucose (analysis)
  • Diabetes Mellitus, Type 2 (blood)
  • Diet, High-Fat
  • Dietary Sucrose (metabolism)
  • Fasting (metabolism)
  • Female
  • Humans
  • Insulin (blood)
  • Insulin Resistance (physiology)
  • Male
  • Mice
  • Mice, Knockout
  • Middle Aged
  • Selenoprotein P (blood, genetics)

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