Abstract | BACKGROUND: METHODOLOGY/PRINCIPAL FINDINGS: We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet. CONCLUSIONS/SIGNIFICANCE:
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Authors | Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, Toshinari Takamura |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 4
Pg. e34952
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 22496878
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Blood Glucose
- Dietary Sucrose
- Insulin
- Selenoprotein P
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Topics |
- Adiponectin
(blood)
- Aged
- Animals
- Blood Glucose
(analysis)
- Diabetes Mellitus, Type 2
(blood)
- Diet, High-Fat
- Dietary Sucrose
(metabolism)
- Fasting
(metabolism)
- Female
- Humans
- Insulin
(blood)
- Insulin Resistance
(physiology)
- Male
- Mice
- Mice, Knockout
- Middle Aged
- Selenoprotein P
(blood, genetics)
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