Abstract | OBJECTIVE: STUDY DESIGN: A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mild preeclampsia. Pooled relative risks with their 95% confidence intervals (CIs) were calculated. RESULTS: Among 7941 citations retrieved, 352 were completely reviewed and four studies (392 women) fulfilled the inclusion criteria and were analyzed. When compared with controls, aspirin started at ≤16 weeks was associated with a significant reduction in severe (relative risk: 0.22, 95% CI: 0.08 to 0.57) but not mild (relative risk: 0.81, 95% CI: 0.33 to 1.96) preeclampsia. CONCLUSION:
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Authors | Stéphanie Roberge, Yves Giguère, Pia Villa, Kypros Nicolaides, Merja Vainio, Jean-Claude Forest, Peter von Dadelszen, Peter von Dadelzen, Daniel Vaiman, Sylvie Tapp, Emmanuel Bujold |
Journal | American journal of perinatology
(Am J Perinatol)
Vol. 29
Issue 7
Pg. 551-6
(Aug 2012)
ISSN: 1098-8785 [Electronic] United States |
PMID | 22495898
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright © 2012 by Thieme Medical Publishers |
Chemical References |
- Platelet Aggregation Inhibitors
- Aspirin
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Topics |
- Aspirin
(therapeutic use)
- Female
- Humans
- Platelet Aggregation Inhibitors
(therapeutic use)
- Pre-Eclampsia
(prevention & control)
- Pregnancy
- Severity of Illness Index
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