HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats].

AbstractOBJECTIVE:
To investigate the effects of alpha-linolenic acid (ALA) on inflammation and oxidative stress in the diabetic rats.
METHODS:
An experimental type 2 diabetes mellitus model was induced by feeding male SD rats with diet of high fat for 4 weeks and then injected them intraperitoneally with streptozocin (STZ) at 30 mg/kg. Then the animals were randomly divided into three groups (n = 10): control group, diabetic group and ALA group. Four weeks later, tumor necrosis factor (TNF)-a, soluble P-selectin (sP-selectin), soluble intercellular adhesion molecule-1 (sICAM-1), nitric oxide (NO) production, malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in the serum were determined.
RESULTS:
Inflammatory agents including TNF-alpha, sP-selectin and sICAM-1 increased in diabetic rats to compare with control group. Treatment with ALA significantly decreased TNF-alpha, sP-selectin and slCAM-1 to compare with diabetic group. Furthermore, compared with control group, serum MDA production increased whereas NO production, SOD and CAT activities decreased in diabetic rats. Treatment with ALA reduced MDA production, increased NO production, promoted SOD and CAT activities compared with diabetic group.
CONCLUSION:
These results indicate that diet rich in ALA exerted the anti-inflammatory and anti-oxidative effects in diabetic rats, which may be beneficial to the prevention and treatment of diabetes.
AuthorsLi-Hua Zhang, Wei Zhang, Guang-Hong Wei, Pei Yang, Jun Liu, Xiao-Lin Niu
JournalZhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 28 Issue 1 Pg. 64-7 (Jan 2012) ISSN: 1000-6834 [Print] China
PMID22493899 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Tumor Necrosis Factor-alpha
  • alpha-Linolenic Acid
  • Malondialdehyde
  • Superoxide Dismutase
Topics
  • Animals
  • Diabetes Mellitus, Experimental (drug therapy, metabolism)
  • Diabetes Mellitus, Type 2 (drug therapy, metabolism)
  • Inflammation
  • Male
  • Malondialdehyde (blood)
  • Oxidative Stress (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Superoxide Dismutase (blood)
  • Tumor Necrosis Factor-alpha (blood)
  • alpha-Linolenic Acid (pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: