Histopathological classification of pseudomyxoma peritonei and the prognostic importance of PINCH protein.

Abstract

AIM:

The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP.

MATERIALS AND METHODS:

Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables.

RESULTS:

The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04).

CONCLUSION:

The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.

• Authors: Håkan Andréasson, Alkwin Wanders, Xiao-Feng Sun, Roger Willén, Wilhelm Graf, Peter Nygren, Bengt Glimelius, Zhi-Yong Zhang, Haile Mahteme
• Journal: Anticancer research (Anticancer Res) Vol. 32 Issue 4 Pg. 1443-8 (Apr 2012) ISSN: 1791-7530 [Electronic] Greece
• PMID: 22493383 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• LIM Domain Proteins
• LIMS1 protein, human
• Membrane Proteins

Topics

• Adaptor Proteins, Signal Transducing (physiology)
• Adult
• Aged
• Female
• Humans
• LIM Domain Proteins (physiology)
• Male
• Membrane Proteins (physiology)
• Middle Aged
• Prognosis
• Pseudomyxoma Peritonei (metabolism)