[Clinical study of oral alendronate in the treatment of pediatric osteogenesis imperfecta].

Abstract

OBJECTIVE:

To explore the clinical efficacy and safety of oral alendronate in children with osteogenesis imperfecta (OI).

METHODS:

Eleven OI children were recruited from August 2008 to April 2011 at Shanghai Institute of Pediatric Research to receive alendronate for a duration of (1.7 ± 0.3) years. The growth, fracture incidence, physical activity, the quality of daily life and safety parameters were evaluated.

RESULTS:

All patients obtained marked improvement. The rates of bone fractures decreased more remarkably than that at pre-treatment (0 - 1.2 fractures per year vs 0.5 - 5.0 fractures per year, medium 0 vs 1.40 fractures per year) (P = 0.003). Their levels of physical activities improved significantly (median level from 4 to 3, P = 0.004). There was significant post-treatment improvement in the self-care activity scores (median score from 43 to 73, P = 0.003). The bone density of lumbar vertebrae, long bones and metaphysis improved at post-treatment. The radiographic examinations revealed the thickness of bone cortex. The change in height did not show any significant difference. No change was found in the serum levels of calcium, phosphorus, parathyroid hormone, alkaline phosphate or other biochemical markers. No adverse reaction occurred throughout treatment.

CONCLUSION:

Oral alendronate treatment reduces the incidence of bone fracture and improves physical activity and life quality in OI children, and as a well-tolerated regimen, it is both safe and effective in clinical practice.

• Authors: Si-si Wei, Qi-xun Cai, Wen-juan Qiu, Li Zhao, Jun Ye, Xiao-lin Wang, Qiu Chen, Xue-fan Gu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 92 Issue 4 Pg. 246-9 (Jan 31 2012) ISSN: 0376-2491 [Print] China
• PMID: 22490796 (Publication Type: Clinical Trial, English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Bone Density Conservation Agents
• Alendronate

Topics

• Adolescent
• Alendronate (administration & dosage, adverse effects, therapeutic use)
• Bone Density Conservation Agents (administration & dosage, adverse effects, therapeutic use)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Male
• Osteogenesis Imperfecta (drug therapy)
• Treatment Outcome