Abstract | BACKGROUND: Intensive treatment such as autologous peripheral blood stem cell (PBSC) transplantation is an important therapeutic strategy in many hematologic malignancies. A number of factors have been reported to impact PBSC mobilization, but the predictive factors varied from one study to another. This retrospective study assessed our current mobilization and collection protocols, and explored the factors predictive of PBSC mobilization in patients with hematologic malignancies. METHODS: RESULTS: The incidence of PM at the first mobilization attempt was 19% (12/64). The PM group was older than the non-PM group (median age, 51 vs. 40 years; P = 0.013). In univariate analysis, there were no significant differences in gender, diagnosis, and body weight between the PM and non-PM groups. A combination of chemotherapy and G-CSF was more effective than G-CSF alone as a mobilizing regimen (P = 0.019). Grade III or IV hematopoietic toxicity of chemotherapy had no significant effect on the mobilization efficacy. Supportive care and the incidence of febrile neutropenia were not significantly different between the two groups. In multivariate analysis, age (odds ratio (OR), 9.536; P = 0.002) and number of previous chemotherapy courses (OR 3.132; P = 0.024) were two independent negative predictive factors for CD34(+) cell yield. PM patients could be managed well by remobilization. CONCLUSION: Older age and a heavy load of previous chemotherapy are the negative risk factors for PBSC mobilization.
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Authors | Shen-miao Yang, Huan Chen, Yu-hong Chen, Hong-hu Zhu, Ting Zhao, Kai-yan Liu |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 125
Issue 4
Pg. 593-8
(Feb 2012)
ISSN: 2542-5641 [Electronic] China |
PMID | 22490480
(Publication Type: Journal Article)
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Chemical References |
- Granulocyte Colony-Stimulating Factor
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Topics |
- Adult
- Aged
- Female
- Granulocyte Colony-Stimulating Factor
(metabolism)
- Hematologic Neoplasms
(metabolism, pathology)
- Hematopoietic Stem Cell Mobilization
- Humans
- Male
- Middle Aged
- Retrospective Studies
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