The efficacy of oral steroids in the treatment of persistent otitis media with effusion.

Abstract

One hundred thirty-six children with otitis media with effusion of at least 2 months' duration were investigated in a strict, double-blind, randomized prospective study to evaluate the efficacy of oral steroids in the treatment of this disease. The results of our study showed a significant complete and partial recovery from otitis media with effusion in the group treated by a combination of antibiotics (amoxicillin) and oral steroids (prednisone), compared with an amoxicillin-treated group and a placebo-treated group. We believe that this treatment mostly benefits children aged 4 to 10 years without oversized adenoids. The findings of our study imply that a combined course of antibiotics and oral steroids deserves its place as a routine conservative trial before surgery.

• Authors: L Podoshin, M Fradis, Y Ben-David, D Faraggi
• Journal: Archives of otolaryngology--head & neck surgery (Arch Otolaryngol Head Neck Surg) Vol. 116 Issue 12 Pg. 1404-6 (Dec 1990) ISSN: 0886-4470 [Print] United States
• PMID: 2248740 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amoxicillin
• Prednisone

Topics

• Administration, Oral
• Amoxicillin (therapeutic use)
• Child
• Child, Preschool
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Humans
• Male
• Otitis Media with Effusion (drug therapy)
• Prednisone (administration & dosage, therapeutic use)
• Prospective Studies