Abstract | OBJECTIVE: To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography. DESIGN: Retrospective clinical case study. SETTING: University veterinary teaching hospital. ANIMALS: Sixty-six dogs (mixed and pure breeds), aged between 4 months and 15 years, weighing between 3.5-61 kg. All animals were classified as ASA score I or II. INTERVENTIONS: Forty-three animals were premedicated with methadone (0.1-0.5 mg/kg) and acepromazine (0.01-0.05 mg/kg) intramuscularly. Twenty-three animals were premedicated with methadone alone (0.1-0.5 mg/kg) intramuscularly. Anesthesia was induced with propofol intravenously and maintained with isoflurane delivered in 100% oxygen. All animals received a balanced isotonic crystalloid solution intravenously at a rate of 10 mL/kg/h. Blood pressure, end-tidal CO(2) , oxygen saturation, respiratory rate, and heart rate were monitored throughout anesthesia. Animals requiring surgery immediately following myelography were excluded from the study. MEASUREMENTS AND MAIN RESULTS: The frequency of seizures was 14% (CI: 3.6-24.3%) and 13.0% (CI: 0.7-27%) in dogs that received methadone/ acepromazine and methadone alone, respectively. There was no significant difference in the frequency of seizures between dogs receiving methadone/ acepromazine or methadone alone (P = 1). Analysis of the association of site of injection of the contrast and the frequency of seizures in dogs receiving methadone/ acepromazine showed no significant difference in the frequency of seizures following cervical injection (25%; CI: 0.5-24.5%) or lumbar injection (9.7%; CI: -0.7-20.1%). CONCLUSIONS:
|
Authors | Eleanor A Drynan, Peter Gray, Anthea L Raisis |
Journal | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
(J Vet Emerg Crit Care (San Antonio))
Vol. 22
Issue 2
Pg. 262-6
(Apr 2012)
ISSN: 1476-4431 [Electronic] United States |
PMID | 22487256
(Publication Type: Journal Article)
|
Copyright | © Veterinary Emergency and Critical Care Society 2012. |
Chemical References |
- Analgesics, Opioid
- Dopamine Antagonists
- Acepromazine
- Methadone
|
Topics |
- Acepromazine
(adverse effects)
- Analgesics, Opioid
(administration & dosage)
- Animals
- Dog Diseases
(chemically induced)
- Dogs
- Dopamine Antagonists
(adverse effects)
- Female
- Male
- Methadone
(administration & dosage)
- Myelography
(veterinary)
- Premedication
(adverse effects, methods, veterinary)
- Retrospective Studies
- Seizures
(chemically induced, veterinary)
|